Description

N3-Peg3-Tbu CAS NO 252881-73-5 is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide (N3) group and a tert-butyl (tBu) protected group. This compound is a critical reagent in bioconjugation and click chemistry, enabling the precise, high-yield coupling of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-purity linkers for developing novel therapeutics, diagnostics, and functional biomaterials.

Application

• Bioconjugation reagent for attaching labels, drugs, or polymers to proteins, antibodies, and peptides.
• Key intermediate in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Surface functionalization of nanoparticles, hydrogels, and biosensors for enhanced biocompatibility and targeting.
• Polymer chemistry for creating functionalized PEG-based materials with clickable handles.
• Cross-linking agent in the development of biomaterials and tissue engineering scaffolds.
• Tool compound in chemical biology for studying biomolecular interactions and cellular processes.
• Precursor for synthesizing more complex heterobifunctional and multifunctional PEG linkers.

Basic Information

Product Name	N3-Peg3-Tbu
CAS No.	252881-73-5
Molecular Formula	C17H35N3O5
Molecular Weight	361.48 g/mol
Synonyms	1-Azido-3,6,9-trioxaundecan-11-yl tert-butyl carbonate; Azido-PEG3-t-butyl ester; N3-PEG3-tBu ester; tert-Butyl 11-azido-3,6,9-trioxaundecanoate; Azido-PEG3-OtBu; Azido-PEG3-t-butyl carbonate; 11-Azido-3,6,9-trioxaundecanoic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our N3-Peg3-Tbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical development. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to verify identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.