Description

5-[n-(6-(Trifluoroacetamido)Hexyl)-3(E)-Acrylamido]-2'-Deoxyuridine is a sophisticated nucleoside analog derivative engineered for advanced biochemical research and pharmaceutical development. This compound matters for its role as a key building block in the synthesis of modified oligonucleotides, enabling precise labeling and cross-linking studies. It is primarily needed by researchers and manufacturers in the fields of molecular diagnostics, antisense therapy development, and bioconjugation chemistry.

Application

• Oligonucleotide Synthesis: Acts as a modified nucleoside precursor for incorporating photoreactive or affinity tags into DNA/RNA strands.
• Bioconjugation & Probe Development: Used to create labeled probes for fluorescence in situ hybridization (FISH), microarray analysis, and other detection platforms.
• Antisense & siRNA Research: Serves as a critical intermediate in the development of novel therapeutic oligonucleotides with enhanced stability and targeting capabilities.
• Cross-linking Studies: The acrylamido moiety facilitates photo-induced cross-linking for studying nucleic acid-protein interactions.
• Diagnostic Assay Development: Enables the creation of highly specific diagnostic tools for genetic and pathogenic detection.
• Academic & Pharmaceutical R&D: A vital reagent for fundamental research in molecular biology, genomics, and drug discovery pipelines.

Basic Information

Product Name	5-[n-(6-(Trifluoroacetamido)Hexyl)-3(E)-Acrylamido]-2'-Deoxyuridine
CAS No.	252337-58-9
Molecular Formula	C₂₀H₂₈F₃N₅O₇
Molecular Weight	507.46 g/mol
Synonyms	5-[N-[6-(Trifluoroacetamido)hexyl]-3-acrylamido]-2'-deoxyuridine; 5-[3-(6-Trifluoroacetamidohexylcarbamoyl)allylamido]-2'-deoxyuridine; 5-(3-Acrylamido-6-trifluoroacetamidohexyl)-2'-deoxyuridine; TFA-Hexyl-Acrylamido-dU; Modified 2'-Deoxyuridine Derivative; Photoreactive Nucleoside; Cross-linking dUTP Analog; Bioconjugation Reagent
EINECS	Contact for details

Quality Control

Every batch of our nucleoside derivatives is produced under strict quality management protocols. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical specifications. Our quality systems are designed to support research and cGMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.