Description

Benzenemethanol, 2,5-Difluoro-4-Methyl- (9Ci) is a fluorinated benzyl alcohol derivative, a versatile and valuable building block in advanced organic synthesis. Its core value lies in the strategic placement of fluorine and methyl substituents on the aromatic ring, which allows for precise modulation of electronic and steric properties in target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for high-performance electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed as a monomer or functionalization agent to introduce fluorine-containing benzyl groups into specialty polymers, improving chemical resistance and surface properties.
• Cross-Coupling Reactions: The benzyl alcohol moiety can be activated for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems.
• Protecting Group Chemistry: Can be utilized in multi-step synthetic routes where the benzyl alcohol group requires temporary protection or subsequent transformation.

Basic Information

Product Name	Benzenemethanol, 2,5-Difluoro-4-Methyl- (9Ci)
CAS No.	252004-43-6
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	2,5-Difluoro-4-methylbenzyl alcohol; (2,5-Difluoro-4-methylphenyl)methanol; 4-Methyl-2,5-difluorobenzyl alcohol; 2,5-Difluoro-4-methyl-benzenemethanol; α-Hydroxy-2,5-difluoro-4-methyltoluene; 2,5-Difluoro-p-tolylmethanol; 1-(Hydroxymethyl)-2,5-difluoro-4-methylbenzene
EINECS	Contact for details

Quality Control

Our Benzenemethanol, 2,5-Difluoro-4-Methyl- (9Ci) is produced under strict quality management systems. We offer material suitable for research and development purposes, with typical purity levels exceeding 95% (by HPLC). All batches are characterized by GC-MS, 1H/19F NMR, and HPLC to ensure identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. For GMP-grade material or custom specifications, please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent oxidation or hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.