Description

Thyroid Hormone Receptor Antagonist, 1-850 is a potent and selective small-molecule compound designed to inhibit the action of thyroid hormone receptors. This matters for researchers and developers as it provides a critical tool for studying thyroid hormone signaling pathways and their role in metabolic regulation, cell differentiation, and potential disease states. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on endocrinology, metabolic disorders, and oncology.

Application

• Biochemical Research: A key reagent for investigating the structure, function, and signaling mechanisms of thyroid hormone receptors (THRα and THRβ).
• Drug Discovery & Development: Used as a reference standard or lead compound in high-throughput screening (HTS) campaigns and preclinical studies targeting thyroid hormone-related pathways.
• Mechanistic Studies: Essential for elucidating the role of thyroid hormone receptors in various physiological and pathological processes, including metabolism, cardiac function, and bone homeostasis.
• Cell-Based Assays: Employed in vitro to modulate thyroid receptor activity in cultured cells to study gene expression, proliferation, and differentiation.
• Endocrinology Research: Supports studies on thyroid hormone resistance syndromes, hyperthyroidism, and related metabolic disorders.
• Oncology Research: Investigated for its potential role in cancers where thyroid hormone receptors are implicated, such as certain hepatic and breast cancers.

Basic Information

Product Name	Thyroid Hormone Receptor Antagonist, 1-850
CAS No.	251310-57-3
Molecular Formula	C23H19F3N2O4S
Molecular Weight	476.47 g/mol
Synonyms	1-850; GC-1; 3,5-Dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)-phenoxy acetic acid; THR Antagonist 1-850; Thyroid receptor antagonist GC-1; Sobetirome analogue; KB-141; TR Antagonist; Selective Thyroid Hormone Receptor Beta Antagonist
EINECS	Contact for details

Quality Control

Our Thyroid Hormone Receptor Antagonist, 1-850 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods (NMR, MS) for structural confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.