Description

5'-Amino-5'-Deoxy-2'-o-Methyl-5-Methyluridine is a chemically modified nucleoside analog, a key building block in oligonucleotide synthesis and medicinal chemistry research. Its unique structure, featuring a 5'-amino group and a 2'-O-methyl modification, is critical for enhancing the stability, binding affinity, and nuclease resistance of synthetic oligonucleotides. This high-purity intermediate is essential for researchers and manufacturers in the fields of antisense therapy, siRNA development, diagnostic probe synthesis, and pharmaceutical R&D.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Therapeutics: Used to create stabilized oligonucleotides with improved pharmacokinetic properties for gene silencing applications.
• Diagnostic Probes: Incorporated into probes for FISH (Fluorescence In Situ Hybridization), PCR, and other molecular diagnostics to increase specificity and stability.
• Medicinal Chemistry & Drug Discovery: Serves as a scaffold for developing novel nucleoside-based antiviral and anticancer agents.
• Bioconjugation: The 5'-amino group provides a handle for labeling with fluorescent dyes, biotin, or other functional groups.
• Academic & Industrial R&D: A valuable tool for studying nucleic acid structure, function, and for exploring new therapeutic modalities.

Basic Information

Product Name	5'-Amino-5'-Deoxy-2'-o-Methyl-5-Methyluridine
CAS No.	251296-69-2
Molecular Formula	C11H17N3O5
Molecular Weight	271.27 g/mol
Synonyms	2'-O-Methyl-5-methyluridine 5'-amine; 5'-Amino-2'-O-methyl-5-methyluridine; 5'-Deoxy-5'-amino-2'-O-methyl-5-methyluridine; 5-Methyl-2'-O-methyluridine 5'-amine; 5'-Amino-5'-deoxy-2'-O-methyl-5-methyluridine; 2'-O-Methyl-5-methyl-5'-aminouridine; 5'-NH2-2'-OMe-5-MeU
EINECS	Contact for details

Quality Control

Our 5'-Amino-5'-Deoxy-2'-o-Methyl-5-Methyluridine is manufactured under strict quality systems suitable for research and pharmaceutical development. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support compliance with ICH guidelines for impurity profiling and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.