Description

1H-Pyrrole-2-Carbonyl Chloride, 5-(Trimethylsilyl)- (9Ci) is a specialized organosilicon-protected pyrrole derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the strategic combination of a reactive acid chloride group and a silyl-protecting group, enabling precise, multi-step functionalization of the pyrrole ring system under controlled conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for constructing complex heterocyclic architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides that incorporate functionalized pyrrole motifs for enhanced biological activity.
• Functional Material Development: Serves as a monomer or precursor for conductive polymers, organic semiconductors, and advanced organic light-emitting diodes (OLEDs).
• Ligand and Catalyst Preparation: Employed in the creation of sophisticated nitrogen-containing ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on heterocyclic chemistry, medicinal chemistry, and organosilicon chemistry.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke, high-value fine chemicals.

Basic Information

Product Name	1H-Pyrrole-2-Carbonyl Chloride, 5-(Trimethylsilyl)- (9Ci)
CAS No.	250722-66-8
Molecular Formula	C8H12ClNOSi
Molecular Weight	201.72 g/mol
Synonyms	5-(Trimethylsilyl)-1H-pyrrole-2-carbonyl chloride; 5-(Trimethylsilyl)pyrrole-2-carboxylic acid chloride; 2-Carbonyl chloride-5-(trimethylsilyl)pyrrole; 5-Trimethylsilyl-1H-pyrrole-2-carbonyl chloride; 5-TMS-pyrrole-2-carbonyl chloride; Pyrrole-2-carbonyl chloride, 5-(trimethylsilyl)-; 250722-66-8
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrole-2-Carbonyl Chloride, 5-(Trimethylsilyl)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and FTIR, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP-compliant manufacturing for advanced pharmaceutical intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a strong acid/organic solvent, hygroscopic (moisture-sensitive), and highly volatile nature, this material must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.