Description

Linaprazan is a potent and selective potassium-competitive acid blocker (P-CAB) used in pharmaceutical research and development. This compound matters for its targeted mechanism of action, which inhibits gastric acid secretion at the final step of the proton pump, offering a promising therapeutic profile. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in developing novel treatments for acid-related disorders such as gastroesophageal reflux disease (GERD) and peptic ulcers.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) in the development of anti-ulcer and anti-reflux medications.
• Biomedical Research: Used as a reference standard and pharmacological tool in in vitro and in vivo studies to investigate gastric acid secretion pathways.
• Drug Discovery: A critical compound for structure-activity relationship (SAR) studies aimed at optimizing next-generation P-CAB therapeutics.
• Analytical Standard: Employed in quality control laboratories for method development, validation, and assay calibration in HPLC and LC-MS systems.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and toxicology studies to support regulatory filings.
• Chemical Synthesis: Acts as a sophisticated building block for medicinal chemists synthesizing novel analogs and derivatives.

Basic Information

Product Name	Linaprazan
CAS No.	248919-64-4
Molecular Formula	C₁₈H₂₀N₄O₂S
Molecular Weight	356.44 g/mol
Synonyms	Linaprazan; AZD0865; 5-(2-Fluorophenyl)-N-[(1S)-1-phenylethyl]-1H-pyrazole-3-carboxamide; Potassium-competitive acid blocker; P-CAB; Gastric proton pump inhibitor; (S)-5-(2-Fluorophenyl)-1-(1-phenylethyl)-1H-pyrazole-3-carboxamide
EINECS	Contact for details

Quality Control

Our Linaprazan is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis by GC, to ensure compliance with high-grade pharmaceutical standards. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each shipment to guarantee traceability and supply chain reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.