Description

tert-Butyl n-(4-Isothiocyanatobutyl)Carbamate is a specialized chemical building block featuring both a protected amine and a reactive isothiocyanate group. This bifunctional nature makes it a valuable intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily used by researchers and process chemists in the life sciences sector for constructing targeted drug candidates and bioconjugates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and targeted therapy research.
• Bioconjugation Reagent: Used to covalently link therapeutic molecules (e.g., drugs, toxins) to antibodies, proteins, or other targeting moieties via amine groups.
• Peptide & Protein Modification: Enables site-specific labeling or functionalization of peptides and proteins for diagnostic and research applications.
• Chemical Probe Synthesis: Facilitates the creation of probes for studying biological pathways and target engagement in drug discovery.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for developing functional polymers with tailored properties.
• Custom Synthesis: A critical starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl n-(4-Isothiocyanatobutyl)Carbamate
CAS No.	247035-47-8
Molecular Formula	C10H18N2O2S
Molecular Weight	230.33 g/mol
Synonyms	1-Boc-4-isothiocyanatobutylamine; N-Boc-1,4-butanediamine isothiocyanate; tert-Butyl (4-isothiocyanatobutyl)carbamate; Boc-NH-(CH2)4-NCS; 4-Isothiocyanato-1-(tert-butoxycarbonylamino)butane; N-(tert-Butoxycarbonyl)-1,4-diaminobutane isothiocyanate; BOC-4-Amino Butyl Isothiocyanate
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(4-Isothiocyanatobutyl)Carbamate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability, consistency, and reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.