Description

9,11-Didehydroestriol is a synthetic derivative of the natural estrogen hormone estriol, characterized by the introduction of an additional double bond in the steroid nucleus. This structural modification is of significant interest in pharmaceutical research for developing novel therapeutic agents and biochemical probes. It serves as a key intermediate and reference standard for researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors, particularly those focused on endocrinology, oncology, and drug discovery.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of novel steroidal drugs and hormone analogs.
• Biochemical Research: Used as a reference standard and analytical reagent in studies investigating estrogen receptor (ER) binding affinity, metabolism, and biological activity.
• Drug Discovery & Development: Employed in high-throughput screening (HTS) and structure-activity relationship (SAR) studies to develop new therapeutic candidates targeting hormone-related conditions.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and method validation in analytical laboratories using HPLC, LC-MS, or GC-MS.
• Academic Research: Utilized in university and institutional labs for fundamental research in steroid chemistry, metabolic pathways, and endocrinology.

Basic Information

Product Name	9,11-Didehydroestriol
CAS No.	246021-20-5
Molecular Formula	C18H22O3
Molecular Weight	286.36 g/mol
Synonyms	9(11)-Dehydroestriol; Estra-1,3,5(10)-triene-3,16α,17β-triol-9(11)-ene; 9,11-Didehydrooestriol; δ9(11)-Estriol; 16α,17β-Dihydroxy-9(11)-dehydroestratrien-3-ol
EINECS	Contact for details

Quality Control

Our 9,11-Didehydroestriol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by chromatographic techniques (HPLC) to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific results for identity, purity, and impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.