Description

5-Methyl-2'-Methoxyethoxycytosine is a modified nucleoside analog of cytosine, featuring a methyl group at the 5-position and a methoxyethoxy moiety on the sugar ring. This specific molecular architecture makes it a valuable intermediate in the synthesis of oligonucleotides and nucleotide-based pharmaceuticals, where it can impart enhanced stability and altered binding properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including antisense oligonucleotides and prodrugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of modified oligonucleotides for therapeutic applications.
• Antisense Drug Development: Used in research and production of antisense oligonucleotides (ASOs) designed to target specific RNA sequences.
• Prodrug Synthesis: Serves as a precursor in creating nucleotide prodrugs aimed at improving drug delivery and bioavailability.
• Biochemical Research: Employed as a substrate or analog in enzymatic studies and nucleic acid chemistry research.
• Diagnostic Probe Development: Can be incorporated into nucleic acid probes for diagnostic assays requiring specific hybridization properties.
• Academic & Industrial R&D: Fundamental material for exploring novel nucleotide modifications and their biological effects.

Basic Information

Product Name	5-Methyl-2'-Methoxyethoxycytosine
CAS No.	244105-55-3
Molecular Formula	C13H19N3O6
Molecular Weight	313.31 g/mol
Synonyms	5-Methyl-2'-O-(2-methoxyethyl)cytidine; 2'-O-Methoxyethyl-5-methylcytidine; 5-Me-2'-MOE-C; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-[[(2-methoxyethoxy)methyl]oxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 5-Methyl-2'-O-(2-methoxyethyl)cytosine; 2'-MOE-5-methylcytidine; N4-Benzoyl-5-methyl-2'-O-(2-methoxyethyl)cytidine (protected form precursor)
EINECS	Contact for details

Quality Control

Our 5-Methyl-2'-Methoxyethoxycytosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.