Description

1-(Methylsulfonyl)-4-Piperidinecarbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound is a critical building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile sulfonyl-piperidine scaffold. It is primarily utilized by research and development teams, as well as production chemists, in the pharmaceutical, agrochemical, and specialty chemical industries to introduce key functional groups into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require the piperidine sulfonamide moiety for biological activity.
• Chemical Research & Development: Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Peptide Mimetic Development: Employed to create constrained peptide analogs and protease inhibitors due to its reactive acid chloride group and cyclic amine structure.
• Material Science Precursor: Can be utilized in the synthesis of specialized polymers or ligands for catalytic systems.

Basic Information

Product Name	1-(Methylsulfonyl)-4-Piperidinecarbonyl Chloride
CAS No.	241138-40-9
Molecular Formula	C7H12ClNO3S
Molecular Weight	225.69 g/mol
Synonyms	4-(Chlorocarbonyl)-1-(methylsulfonyl)piperidine; 1-Methanesulfonylpiperidine-4-carbonyl chloride; 4-Piperidinecarbonyl chloride, 1-(methylsulfonyl)-; 1-(Methylsulfonyl)piperidine-4-carboxylic acid chloride; NSC 405124; 1-(Methylsulphonyl)piperidine-4-carbonyl chloride; 1-Methylsulfonyl-4-piperidinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 1-(Methylsulfonyl)-4-Piperidinecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.