Description

7,27-Dihydroxycholesterol is a specialized oxysterol derivative of cholesterol, serving as a key intermediate and reference standard in biochemical research. This compound matters for its role in studying cholesterol metabolism, bile acid biosynthesis, and the activation of liver X receptors (LXRs), which are critical targets in metabolic and cardiovascular disease research. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of high-purity biochemical reagents for use in metabolic pathway analysis and drug discovery programs.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in analytical methods such as HPLC and LC-MS for the quantification of oxysterols in biological samples.
• Metabolic Pathway Studies: A critical intermediate for investigating the enzymatic pathways of cholesterol catabolism and bile acid synthesis.
• Cell Signaling Research: Employed in studies of Liver X Receptor (LXR) activation and regulation, which influences lipid metabolism and inflammatory responses.
• Pharmaceutical Development: Serves as a starting material or intermediate in the synthesis of novel therapeutic agents targeting metabolic disorders.
• Diagnostic Reagent Manufacturing: Utilized in the production of calibrators and controls for clinical diagnostic assays related to cholesterol metabolism.

Basic Information

Product Name	7,27-Dihydroxycholesterol
CAS No.	240129-43-5
Molecular Formula	C27H46O3
Molecular Weight	418.66 g/mol
Synonyms	7α,27-Dihydroxycholesterol; (3β,7α)-7,27-Dihydroxycholest-5-en-3-ol; 7α-Hydroxy-27-hydroxycholesterol; 27-Hydroxy-7α-hydroxycholesterol; 7,27-DiOHC; Oxysterol 7,27-diOH; 5-Cholestene-3β,7α,27-triol
EINECS	Contact for details

Quality Control

Our 7,27-Dihydroxycholesterol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.