Description

2-(Trifluoromethyl)-5-[4-(Trifluoromethyl)Phenyl]-3-Furoyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive acid chloride group and trifluoromethyl-substituted aromatic system. This compound is essential for introducing the highly stable and lipophilic trifluoromethylphenyl-furoyl moiety into target molecules, significantly altering their physical and biological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its unique structure enables the fine-tuning of potency, metabolic stability, and bioavailability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance lipid permeability and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for constructing complex heterocyclic compounds and for peptide coupling reactions via its reactive acyl chloride functionality.
• Fluorinated Compound Library Development: A critical reagent for medicinal chemistry teams building diverse screening libraries to explore structure-activity relationships (SAR) in drug discovery projects.

Basic Information

Product Name	2-(Trifluoromethyl)-5-[4-(Trifluoromethyl)Phenyl]-3-Furoyl Chloride
CAS No.	240122-23-0
Molecular Formula	C13H5ClF6O2
Molecular Weight	342.62 g/mol
Synonyms	5-[4-(Trifluoromethyl)phenyl]-2-(trifluoromethyl)furan-3-carbonyl chloride; 2-(Trifluoromethyl)-5-(4-(trifluoromethyl)phenyl)furan-3-carbonyl chloride; 3-Furoyl chloride, 2-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]-; 240122-23-0; 5-(4-Trifluoromethylphenyl)-2-trifluoromethyl-3-furoyl chloride
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)-5-[4-(Trifluoromethyl)Phenyl]-3-Furoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent derivative and reactive acid chloride, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and separated from moisture, bases, and oxidizing agents. Use appropriate corrosion-resistant containment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.