Description

2'-Deoxy-N2,N2-Diethyl Guanosine is a chemically modified nucleoside analog, specifically a derivative of deoxyguanosine where the exocyclic amino group is diethylated. This modification is crucial for enhancing the molecule's lipophilicity and altering its interaction with biological targets, making it a valuable building block in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and research scientists in the fields of antiviral and anticancer drug discovery, as well as in the synthesis of oligonucleotide probes. Our supply ensures high-purity material, supporting critical R&D and scale-up processes with reliable quality and consistency.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel nucleoside-based therapeutics, including antiviral and anticancer agents.
• Antiviral Drug Research: Used in the design and synthesis of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oligonucleotide Synthesis: Serves as a modified phosphoramidite or solid-support precursor for creating specialized oligonucleotides for diagnostic and research applications.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Prodrug Development: The diethyl modification can be leveraged to improve the pharmacokinetic properties, such as membrane permeability and metabolic stability, of lead compounds.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in pharmaceutical manufacturing.

Basic Information

Product Name	2'-Deoxy-N2,N2-Diethyl Guanosine
CAS No.	236389-19-8
Molecular Formula	C₁₄H₂₁N₅O₄
Molecular Weight	323.35 g/mol
Synonyms	N2,N2-Diethyl-2'-deoxyguanosine; 2'-Deoxy-N2,N2-diethylguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(diethylamino)-1H-purin-2-one; Diethylamino-deoxyguanosine; N2,N2-Diethyl-dG; 2'-dG(N2-Et)2; Guanosine, 2'-deoxy-N2,N2-diethyl-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-N2,N2-Diethyl Guanosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to cGMP guidelines where applicable to support our clients' regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.