Description

n-Acetyl-5'-Dmt Guanosine is a key nucleoside derivative, specifically engineered for oligonucleotide synthesis. This compound matters for its role as a critical building block in the production of high-purity, modified DNA and RNA sequences, enabling advanced research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense technology, siRNA, and diagnostic probe manufacturing.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A crucial phosphoramidite precursor for the automated synthesis of modified oligonucleotides.
• Antisense & siRNA Therapeutic Development: Used in the manufacture of research-grade and therapeutic oligonucleotides targeting specific genes.
• Diagnostic Probe Fabrication: Essential for creating labeled probes used in PCR, FISH, and other molecular diagnostic assays.
• Structural Biology & Biochemistry Research: Serves as a modified nucleoside standard for studying nucleic acid structure, function, and interactions.
• GMP-Grade API Intermediate: A potential starting material or intermediate in the cGMP production of oligonucleotide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	n-Acetyl-5'-Dmt Guanosine
CAS No.	231957-27-0
Molecular Formula	C33H35N5O8
Molecular Weight	629.66 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N2-acetylguanosine; N-Acetyl-5'-O-DMT-guanosine; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-acetyl-; DMT-G(Ac) Phosphoramidite precursor; 2'-Deoxy-N2-acetyl-5'-O-(4,4'-dimethoxytrityl)guanosine; N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine; Protected Guanosine Derivative
EINECS	Contact for details

Quality Control

Our n-Acetyl-5'-Dmt Guanosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques like HPLC and NMR. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.