Description

N6-Acetyl-5'-o-(4,4'-Dimethoxytrityl)Adenosine is a key protected nucleoside derivative used as a critical building block in oligonucleotide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates for the production of DNA/RNA sequences, antisense oligonucleotides, and other nucleic acid-based therapeutics. It is primarily utilized by the pharmaceutical, biotechnology, and life sciences industries engaged in advanced research and development.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for solid-phase synthesis of DNA and RNA strands.
• Antisense Drug Development: Used in the manufacture of antisense oligonucleotides for therapeutic applications targeting genetic diseases.
• Research Reagent: Serves as a high-purity intermediate in academic and industrial research laboratories for nucleic acid chemistry.
• siRNA and miRNA Production: A building block in the synthesis of small interfering RNA (siRNA) and microRNA (miRNA) for gene silencing studies.
• Diagnostic Probe Synthesis: Employed in the creation of labeled probes for diagnostic assays and genomic testing.
• Pharmaceutical Intermediates: Acts as a protected intermediate in the multi-step synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	N6-Acetyl-5'-o-(4,4'-Dimethoxytrityl)Adenosine
CAS No.	231957-26-9
Molecular Formula	C35H35N5O7
Molecular Weight	637.69 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-acetyladenosine; N6-Acetyl-5'-O-DMT-adenosine; DMT-N6-Acetyladenosine; 5'-O-DMT-N6-Ac-Ado; Adenosine, N6-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-; N6-Ac-5'-O-DMT-Adenosine; 5'-O-(Bis(4-methoxyphenyl)phenylmethyl)-N6-acetyladenosine
EINECS	Contact for details

Quality Control

Our N6-Acetyl-5'-o-(4,4'-Dimethoxytrityl)Adenosine is manufactured under strict quality control protocols to ensure it meets the high-purity standards required for sensitive oligonucleotide synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.