Description

5-[4-((3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)Amino)Quinazolin-6-Yl]-2-Furaldehyde is a high-purity, advanced pharmaceutical intermediate designed for research and development in targeted therapies. This compound is critical for its role as a key building block in the synthesis of novel kinase inhibitors, offering researchers a reliable and well-characterized starting material. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology and signal transduction pathway research.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of investigational small-molecule drugs, particularly kinase inhibitors.
• Oncology Research: Used in the development and study of targeted cancer therapies that inhibit specific tyrosine kinases involved in tumor growth and proliferation.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening (HTS) and enzymatic assays to study inhibitor activity.
• Academic & Contract Research: Utilized by universities and CROs (Contract Research Organizations) for basic research into cellular signaling pathways and drug discovery projects.
• Process Chemistry & Scale-Up: Acts as a defined intermediate for process optimization and the scale-up synthesis of active pharmaceutical ingredients (APIs).
• Custom Synthesis: Provides a foundation for the custom synthesis of structurally related analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	5-[4-((3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)Amino)Quinazolin-6-Yl]-2-Furaldehyde
CAS No.	231278-84-5
Molecular Formula	C26H17ClFN3O3
Molecular Weight	473.89 g/mol
Synonyms	5-[4-[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl)amino]quinazolin-6-yl]-2-furaldehyde; 2-Furaldehyde, 5-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-; TAK-285 Intermediate; Kinase Inhibitor Intermediate; 231278-84-5; 5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our 5-[4-((3-Chloro-4-((3-Fluorobenzyl)Oxy)Phenyl)Amino)Quinazolin-6-Yl]-2-Furaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.