Description

Cyclopropanecarbonyl Chloride, 3-[(1E)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3R)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereochemistry and fluorinated motifs are critical for function.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the cyclopropane and fluoroalkene groups can impart unique biological activity and metabolic stability.
• Fluorine Chemistry: Serves as a specialized reagent for introducing fluorinated, propenyl-substituted cyclopropane scaffolds into target molecules, a valuable transformation in modern synthetic methodology.
• Asymmetric Synthesis: Employed in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity, leveraging its defined (1R,3R) configuration.
• Ligand & Catalyst Development: Potential precursor for creating novel chiral ligands or organocatalysts used in asymmetric catalysis.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with potential unique optical or electronic properties.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 3-[(1E)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3R)- (9Ci)
CAS No.	228703-09-1
Molecular Formula	C9H12ClFO
Molecular Weight	190.64 g/mol
Synonyms	(1R,3R)-3-[(1E)-2-Fluoroprop-1-en-1-yl]-2,2-dimethylcyclopropane-1-carbonyl chloride; (1R,3R)-3-[(E)-2-Fluoro-1-propenyl]-2,2-dimethylcyclopropanecarbonyl chloride; (1R,3R)-rel-3-[(1E)-2-Fluoro-1-propen-1-yl]-2,2-dimethylcyclopropanecarbonyl chloride; (1R,3R)-3-[(E)-2-Fluoroprop-1-enyl]-2,2-dimethylcyclopropanecarboxylic acid chloride; (1R,3R)-3-(2-Fluoro-1-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride; Fluorinated Chiral Cyclopropanecarbonyl Chloride; (1R,3R)-Isomer of CAS 228703-09-1
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 3-[(1E)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3R)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. We employ advanced analytical techniques including chiral HPLC, GC, NMR, and MS to verify identity, isomeric purity, and chemical composition. Certificates of Analysis (COA) detailing specific lot results are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, it should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage and opened with care to exclude moisture. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (for (1R,3R) isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.