Description

Cyclopropanecarbonyl Chloride, 3-[(1Z)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3S)- (9Ci) is a high-purity, chiral organofluorine building block of significant interest in advanced synthetic chemistry. Its value lies in the precise stereochemistry and reactive acid chloride functional group, enabling the efficient construction of complex molecular architectures. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the cyclopropane and fluoroalkene motifs can enhance biological activity.
• Material Science Research: Serves as a precursor for specialty polymers or liquid crystals that incorporate stereodefined, fluorinated units.
• Asymmetric Catalysis Ligand Precursor: The chiral backbone can be utilized to develop novel ligands for catalytic asymmetric transformations.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical manufacturers offering bespoke synthesis services for clients.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 3-[(1Z)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3S)- (9Ci)
CAS No.	228702-64-5
Molecular Formula	C9H12ClFO
Molecular Weight	190.64 g/mol
Synonyms	(1R,3S)-3-[(1Z)-2-Fluoroprop-1-en-1-yl]-2,2-dimethylcyclopropane-1-carbonyl chloride; (1R,3S)-3-[(Z)-2-Fluoro-1-propenyl]-2,2-dimethylcyclopropanecarbonyl chloride; (1R,3S)-rel-3-[(1Z)-2-Fluoro-1-propen-1-yl]-2,2-dimethylcyclopropanecarboxylic acid chloride; (1R-cis)-3-[(Z)-2-Fluoropropenyl]-2,2-dimethylcyclopropanecarbonyl chloride; Chiral fluorinated cyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarbonyl Chloride, 3-[(1Z)-2-Fluoro-1-Propenyl]-2,2-Dimethyl-, (1R,3S)- (9Ci) is produced and controlled under a strict quality management system. Our products undergo rigorous quality testing, including chiral purity analysis, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC/NMR), enantiomeric excess, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to maintain stability and minimize degradation of this moisture-sensitive and highly volatile acid chloride. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.