Description

Taltobulin (Trifluoroacetate) is a synthetic small molecule tubulin polymerization inhibitor with significant research and therapeutic potential. This compound matters for its targeted mechanism of action, which disrupts microtubule dynamics in rapidly dividing cells. It is primarily needed by pharmaceutical researchers and developers in the fields of oncology and cell biology for drug discovery, preclinical studies, and as a reference standard. The product is supplied as a high-purity material suitable for advanced scientific applications.

Application

• Oncology Research: As a potent vascular disrupting agent (VDA) and tubulin inhibitor for studying cancer cell proliferation, angiogenesis, and metastasis.
• Drug Discovery & Development: Serving as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel chemotherapeutic agents.
• Biochemical Research: Used as a precise tool to investigate microtubule dynamics, cell cycle arrest, and cytoskeleton function in vitro.
• Reference Standard: Providing a certified material for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy and pharmacokinetics of anti-tumor therapies.

Basic Information

Product Name	Taltobulin (Trifluoroacetate)
CAS No.	228266-41-9
Molecular Formula	C₂₀H₂₀F₃N₅O₅
Molecular Weight	467.40 g/mol
Synonyms	Taltobulin TFA; Taltobulin trifluoroacetate salt; N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine trifluoroacetate; VERU-111; ABT-751 analogue; Tubulin polymerization inhibitor VERU-111; Vascular Disrupting Agent (VDA) Taltobulin.
EINECS	Contact for details

Quality Control

Our Taltobulin (Trifluoroacetate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the material should be handled in a dry environment and allowed to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.