Description

Tandutinib CAS NO 228266-40-8 is a potent and selective small-molecule inhibitor of FMS-like tyrosine kinase 3 (FLT3) and platelet-derived growth factor receptor (PDGFR). This compound is of significant value in oncology research and development, specifically targeting signaling pathways implicated in the proliferation and survival of certain cancer cells. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and CROs (Contract Research Organizations) engaged in the discovery of novel therapeutics for hematological malignancies and solid tumors.

Application

• Oncology Research: Used as a critical pharmacological tool to study FLT3 and PDGFR signaling pathways in cancer cell biology.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of targeted kinase inhibitor therapies.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro kinase assays to evaluate inhibitor potency and selectivity.
• Preclinical Studies: Utilized in animal models to investigate the efficacy, pharmacokinetics, and pharmacodynamics of FLT3/PDGFR inhibition.
• Mechanism of Action (MoA) Studies: Aids in understanding resistance mechanisms and combination therapy strategies for cancers like acute myeloid leukemia (AML) and glioblastoma.
• Reference Standard: Functions as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.

Basic Information

Product Name	Tandutinib
CAS No.	228266-40-8
Molecular Formula	C₂₁H₂₀FN₅O₃
Molecular Weight	409.41 g/mol
Synonyms	MLN 518; CT53518; 6,7-Dimethoxy-2-[(1E)-1-(1-methyl-1H-indol-3-yl)-2-nitroethenyl]-4-quinazolinamine; N-(3-Fluorophenyl)-2-[(1-methyl-1H-indol-3-yl)methylene]-4-oxo-1,3-thiazolidine-5-carboxamide; FLT3 Inhibitor MLN518; PDGFR Inhibitor MLN518
EINECS	Contact for details

Quality Control

Every batch of Tandutinib is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements of research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from HPLC, NMR, and mass spectrometry analyses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.