Description

Dimethyl Trimethylsilyl Propargylphosphonate is a specialized organophosphorus reagent featuring both propargyl and silyl-protected phosphonate functionalities. This compound matters as a versatile building block in modern synthetic chemistry, enabling the efficient introduction of phosphorus-containing alkynyl groups. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those containing phosphonate or alkyne moieties.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides with tailored biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine-based ligands and organocatalysts.
• Material Science Research: Employed in the synthesis of functionalized polymers, dendrimers, and advanced organic materials.
• Cross-Coupling Reactions: Acts as a propargylphosphonate donor in metal-catalyzed cross-coupling and homologation reactions.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new reaction pathways in organic synthesis.

Basic Information

Product Name	Dimethyl Trimethylsilyl Propargylphosphonate
CAS No.	228120-29-4
Molecular Formula	C9H19O3PSi
Molecular Weight	234.31 g/mol
Synonyms	Dimethyl (3-(Trimethylsilyl)-2-propyn-1-yl)phosphonate; (3-(Trimethylsilyl)prop-2-yn-1-yl)phosphonic Acid Dimethyl Ester; Propargylphosphonic Acid Dimethyl Ester Trimethylsilyl Derivative; TMS-Propargylphosphonate Dimethyl Ester; Dimethyl P-(3-Trimethylsilyl-2-propynyl)phosphonate; DTSPP; CAS 228120-29-4
EINECS	Contact for details

Quality Control

Our Dimethyl Trimethylsilyl Propargylphosphonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.