Description

2H-1-Benzopyran-2-Carbonylchloride,3,4-Dihydro-,(2R)-(9Ci) is a high-purity, chiral chemical intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the dihydrobenzopyran scaffold with precise stereocontrol.

Application

• Pharmaceutical Intermediate: A crucial chiral precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and metabolic conditions.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where the specific stereochemistry of the dihydrobenzopyran core influences biological activity.
• Fine Chemical Production: Serves as a specialized building block for creating complex fragrances, flavors, and functional materials that require high enantiomeric purity.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in asymmetric synthesis and the development of new catalytic processes.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Product Name	2H-1-Benzopyran-2-Carbonylchloride,3,4-Dihydro-,(2R)-(9Ci)
CAS No.	227466-91-3
Molecular Formula	C10H9ClO2
Molecular Weight	196.63 g/mol
Synonyms	(2R)-3,4-Dihydro-2H-1-benzopyran-2-carbonyl chloride; (R)-3,4-Dihydro-2H-chromene-2-carbonyl chloride; (R)-Chroman-2-carbonyl chloride; (2R)-Chroman-2-carbonyl chloride; (R)-2-Chromancarbonyl chloride; (R)-Dihydrobenzopyran-2-carbonyl chloride; (2R)-3,4-Dihydro-2H-chromene-2-carbonyl chloride; (R)-3,4-Dihydro-2H-1-benzopyran-2-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 2H-1-Benzopyran-2-Carbonylchloride,3,4-Dihydro-,(2R)-(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and titration for assay. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.