Description

1,3-Dioxolane-4,5-Dicarbonyldichloride,(4R,5R)-Rel-(9Ci) is a high-purity, chiral chemical building block of significant importance in advanced organic synthesis. Its value lies in its role as a versatile, reactive intermediate for constructing complex, stereochemically defined molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), especially those requiring specific stereochemistry.
• Asymmetric Synthesis: Used in the construction of complex, enantiomerically pure molecules for applications in medicinal chemistry and catalysis.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized chiral ligands and organocatalysts used in stereoselective transformations.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value specialty chemicals, agrochemicals, and advanced materials.
• Academic and Industrial R&D: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	1,3-Dioxolane-4,5-Dicarbonyldichloride,(4R,5R)-Rel-(9Ci)
CAS No.	227316-93-0
Molecular Formula	C5H4Cl2O4
Molecular Weight	198.99 g/mol
Synonyms	(4R,5R)-1,3-Dioxolane-4,5-dicarbonyl dichloride; (4R,5R)-4,5-Dicarbonyl-1,3-dioxolane dichloride; (4R,5R)-Dioxolane-4,5-dicarboxylic acid dichloride; (4R,5R)-rel-1,3-Dioxolane-4,5-dicarboxylic acid chloride; (4R-cis)-1,3-Dioxolane-4,5-dicarbonyl Dichloride; Chiral Dioxolane Dicarboxylic Acid Dichloride; (9CI) reference compound.
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4,5-Dicarbonyldichloride,(4R,5R)-Rel-(9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.