Description

N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-Fluoro-2'-Deoxy-Arabinoadenosine is a high-purity, protected nucleoside phosphoramidite precursor, a critical building block in the automated synthesis of oligonucleotides. Its value lies in enabling the precise and efficient incorporation of a 2'-fluoro-arabinonucleotide (FANA) modification, which significantly enhances the nuclease resistance and binding affinity of therapeutic oligonucleotides. This compound is essential for research institutions and pharmaceutical companies developing advanced antisense, siRNA, and aptamer-based therapeutics, diagnostics, and research tools.

Application

• Therapeutic Oligonucleotide Synthesis: As a key phosphoramidite monomer for the solid-phase synthesis of antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) containing 2'-F-ANA modifications.
• Aptamer Development: For constructing chemically modified nucleic acid aptamers with improved stability and target affinity for diagnostic and therapeutic applications.
• Research & Development: Used in academic and industrial labs to study the structure-activity relationships (SAR) of modified oligonucleotides and to prototype novel genetic medicines.
• Diagnostic Probe Manufacture: Incorporation into fluorescent or detection probes that require enhanced resistance to enzymatic degradation in complex biological samples.
• Process Development & Scale-Up: Serves as a critical raw material for process chemistry teams scaling up GMP-grade oligonucleotide active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	N6-Benzoyl-5'-O-(4,4'-Dimethoxytrityl)-2'-Fluoro-2'-Deoxy-Arabinoadenosine
CAS No.	226415-08-3
Molecular Formula	C44H38FN5O7
Molecular Weight	767.80 g/mol
Synonyms	2'-F-ANA-A(Bz)-DMT; 2'-Fluoro-2'-deoxy-arabinoadenosine, N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-fluoro-2'-deoxy-arabinoadenosine; 2'-F-Arabinoadenosine phosphoramidite precursor; 2'-F-ANA-ABz DMT; 9-[(2R,3S,4S,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-benzoylaminopurine
EINECS	Contact for details

Quality Control

Our production of this advanced nucleic acid building block adheres to stringent quality protocols suitable for research and pre-clinical development. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing the analytical results. For projects requiring regulatory support, we can discuss custom synthesis under controlled conditions to meet specific quality benchmarks.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.