Description

(S)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol is a high-value chiral intermediate characterized by its electron-deficient aromatic ring system and trifluoromethyl groups. This compound is crucial for its role as a key building block in the synthesis of advanced pharmaceutical agents and agrochemicals, where its specific stereochemistry and fluorine substitution pattern impart desirable biological activity and metabolic stability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of NK1 receptor antagonists, such as Aprepitant and Fosaprepitant, used for the prevention of chemotherapy-induced and postoperative nausea and vomiting.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the trifluoromethyl groups enhance lipophilicity and biological activity.
• Catalyst and Ligand Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and polymers with specific electronic properties.
• Process Chemistry & Scale-up: Used in pilot plants and commercial manufacturing for the production of high-value active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol
CAS No.	225920-05-8
Molecular Formula	C10H8F6O
Molecular Weight	258.16 g/mol
Synonyms	(S)-[3,5-Bis(trifluoromethyl)phenyl]ethanol; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-ol; (S)-α-(3,5-Bis(trifluoromethyl)phenyl)ethyl alcohol; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethyl alcohol; (S)-3,5-Bis(trifluoromethyl)benzeneethanol; (S)-Aprepitant Intermediate; (S)-Fosaprepitant Intermediate; LFA-1 Antagonist Intermediate
EINECS	Contact for details

Quality Control

Our production of (S)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Every lot is analyzed using advanced techniques including HPLC, GC, and chiral analysis to confirm identity, potency, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.