Description

Retapamulin is a semi-synthetic pleuromutilin derivative antibiotic specifically developed for topical use. This compound is valued for its potent activity against Gram-positive bacteria, including strains resistant to other antibiotic classes. It is a critical active pharmaceutical ingredient (API) for the formulation of topical antimicrobial ointments and creams, primarily targeting the pharmaceutical and veterinary medicine industries for the treatment of skin infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in topical antibacterial ointments, such as those prescribed for impetigo and other primary skin infections.
• Veterinary Medicine: Formulation into topical preparations for treating bacterial skin infections in companion animals and livestock.
• Antimicrobial Research: Serves as a reference standard and key compound in microbiological research for studying bacterial protein synthesis inhibition and mechanisms of antibiotic resistance.
• Drug Development: Used in R&D for developing new pleuromutilin-based antibiotic formulations with improved delivery systems or spectra of activity.

Basic Information

Product Name	Retapamulin
CAS No.	224452-66-8
Molecular Formula	C30H47NO5S
Molecular Weight	533.77 g/mol
Synonyms	SB-275833; (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl [(2S)-2-amino-3-methyl-1-oxobutyl]amino]ethanethioate; Altargo (trade name); Pleuromutilin derivative
EINECS	Contact for details

Quality Control

Our Retapamulin is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality assurance protocols are designed to ensure identity, purity, strength, and composition, referencing pharmacopeial guidelines where applicable. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and microbiological quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5%; Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Microbial Limits	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.