Description

4-Isothiocyanato-N,n-Dimethylbenzenesulfonamide is a specialized organic intermediate featuring a reactive isothiocyanate group attached to a dimethylbenzenesulfonamide core. This compound matters for its role as a versatile building block in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and life sciences industries for applications such as medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting enzyme inhibition or protein binding.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, or pesticides by acting as a reactive moiety for constructing active molecules.
• Bioconjugation & Probe Synthesis: The isothiocyanate group readily reacts with amines, making it useful for labeling proteins, antibodies, or other biomolecules for diagnostic or research purposes.
• Material Science Chemistry: Serves as a monomer or cross-linking agent in the development of specialized polymers with unique thermal or chemical properties.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) or other chemoproteomic strategies to study enzyme function and discover new targets.

Basic Information

Product Name	4-Isothiocyanato-N,n-Dimethylbenzenesulfonamide
CAS No.	223785-92-0
Molecular Formula	C9H10N2O2S2
Molecular Weight	242.32 g/mol
Synonyms	N,N-Dimethyl-4-isothiocyanatobenzenesulfonamide; 4-Isothiocyanato-N,N-dimethylbenzenesulfonamide; Benzenesulfonamide, N,N-dimethyl-4-isothiocyanato-; p-(Dimethylsulfamoyl)phenyl isothiocyanate; 4-(Dimethylsulfamoyl)phenyl isothiocyanate; NSC 405124; 223785-92-0
EINECS	Contact for details

Quality Control

Our 4-Isothiocyanato-N,n-Dimethylbenzenesulfonamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.