Description

2'-o-(2-Methoxyethyl)Uridine is a chemically modified nucleoside, a critical building block in the synthesis of oligonucleotides. This modification is essential for enhancing the stability, specificity, and pharmacokinetic properties of therapeutic nucleic acids. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of advanced antisense oligonucleotides, siRNA, and mRNA-based therapeutics.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key monomer for creating oligonucleotides with improved nuclease resistance and binding affinity to target RNA.
• Small Interfering RNA (siRNA) Production: Used to incorporate 2'-MOE modifications, which are crucial for increasing siRNA stability in vivo and reducing off-target effects.
• Therapeutic mRNA Development: Serves as a modified nucleoside triphosphate precursor for in vitro transcription to produce mRNA with enhanced translational efficiency and reduced immunogenicity.
• Aptamer and Diagnostic Probe Design: Employed to engineer nucleic acid probes with superior stability for diagnostic and sensor applications.
• Medicinal Chemistry & Drug Discovery: A vital intermediate in the research and development of novel nucleoside-based pharmaceuticals targeting viral infections and genetic disorders.
• Bioconjugation and Labeling: Provides a reactive handle for further chemical modifications and attachment of reporter molecules or delivery vehicles.

Basic Information

Product Name	2'-o-(2-Methoxyethyl)Uridine
CAS No.	223777-15-9
Molecular Formula	C12H18N2O7
Molecular Weight	302.28 g/mol
Synonyms	2'-O-Methoxyethyluridine; 2'-MOE-Uridine; 2'-O-(2-Methoxyethyl)uridine; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]pyrimidine-2,4-dione; Uridine, 2'-O-(2-methoxyethyl)-; 5'-O-DMT-2'-O-MOE-uridine (protected form); MOE-U
EINECS	Contact for details

Quality Control

Every batch of 2'-o-(2-Methoxyethyl)Uridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for pharmaceutical research and GMP applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.