Description

1-Pyrrolidinecarbonyl Chloride, 2-Phenyl- (9Ci) is a specialized organic building block featuring a reactive acid chloride group on a substituted pyrrolidine scaffold. This compound matters as a key reagent for introducing the 2-phenylpyrrolidine-1-carbonyl moiety, enabling the synthesis of complex molecules with potential biological activity. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the pyrrolidine structure can contribute to biological efficacy.
• Peptidomimetic Chemistry: Serves as a precursor for creating peptidomimetics and protease inhibitors by acylating amino groups.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for labeling or modifying biomolecules to create tools for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Item	Detail
Product Name	1-Pyrrolidinecarbonyl Chloride, 2-Phenyl- (9Ci)
CAS No.	223375-92-6
Molecular Formula	C11H12ClNO
Molecular Weight	209.67 g/mol
Synonyms	2-Phenylpyrrolidine-1-carbonyl chloride; 1-Carbamoyl-2-phenylpyrrolidine chloride; 2-Phenyl-1-pyrrolidinecarbonyl chloride; (2-Phenylpyrrolidin-1-yl)methanoyl chloride; 2-Phenyl-N-chlorocarbonylpyrrolidine; 1-Chloroformyl-2-phenylpyrrolidine; 2-Phenylpyrrolidine-1-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarbonyl Chloride, 2-Phenyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.