Description

4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoyl chloride is a high-purity, reactive chemical intermediate featuring a benzoyl chloride group linked to a substituted 1,2,4-oxadiazole heterocycle. This compound is critically important for its role as a key building block in the synthesis of more complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the 1,2,4-oxadiazole moiety.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymers with specific thermal or optical properties.
• Ligand and Probe Development: Employed in medicinal chemistry for creating targeted molecular probes and enzyme inhibitors due to its ability to form stable amide bonds.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoyl Chloride
CAS No.	222541-76-6
Molecular Formula	C10H7ClN2O2
Molecular Weight	222.63 g/mol
Synonyms	4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoyl chloride; 4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid chloride; 3-(4-Chlorocarbonylphenyl)-5-methyl-1,2,4-oxadiazole; 5-Methyl-3-(4-chlorocarbonylphenyl)-1,2,4-oxadiazole; [4-(5-Methyl-1,2,4-oxadiazol-3-yl)phenyl]carbonyl chloride; Benzoyl chloride, 4-(5-methyl-1,2,4-oxadiazol-3-yl)-
EINECS	Contact for details

Quality Control

Our 4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoyl chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support development work that may progress to cGMP production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis of the acid chloride functionality. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.