Description

5-(Chloroformyl)-2,4-Difluoronitrobenzene, also known as 5-(Chlorocarbonyl)-2,4-difluoronitrobenzene, is a versatile and highly reactive aromatic building block. Its value lies in its trifunctional structure, incorporating a reactive acid chloride group, fluorine substituents, and a nitro group, making it a critical intermediate for constructing complex molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the difluoronitrobenzene scaffold is required.
• Material Science Precursor: Serves as a monomer or precursor for specialized polymers and liquid crystals.
• Organic Synthesis Reagent: Employed in coupling reactions, such as amide bond formation, via its reactive acid chloride functionality.
• Fluorine Chemistry Research: Essential for studying structure-activity relationships (SAR) in medicinal chemistry due to the presence of fluorine atoms.
• Dye and Pigment Intermediate: Used in the synthesis of complex aromatic dyes and functional pigments.

Basic Information

Product Name	5-(Chloroformyl)-2,4-Difluoronitrobenzene
CAS No.	221560-09-4
Molecular Formula	C7H2ClF2NO3
Molecular Weight	221.55 g/mol
Synonyms	5-(Chlorocarbonyl)-2,4-difluoronitrobenzene; 2,4-Difluoro-5-nitrobenzoyl chloride; 5-Nitro-2,4-difluorobenzoyl chloride; 2,4-Difluoro-5-nitrobenzoic acid chloride; Benzoyl chloride, 2,4-difluoro-5-nitro-; 5-Carboxy-2,4-difluoronitrobenzene chloride
EINECS	Contact for details

Quality Control

Our 5-(Chloroformyl)-2,4-Difluoronitrobenzene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.