Description

(4-Bromo-2-(Trifluoromethoxy)Phenyl)Methanol is a versatile brominated and fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromine and trifluoromethoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, as well as by material scientists exploring specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved device performance.
• Polymer Modification: Employed to introduce functional aromatic groups into polymer backbones, modifying thermal stability and optical properties for advanced material applications.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry research in both academic and industrial settings.

Basic Information

Product Name	(4-Bromo-2-(Trifluoromethoxy)Phenyl)Methanol
CAS No.	220996-81-6
Molecular Formula	C8H6BrF3O2
Molecular Weight	271.04 g/mol
Synonyms	4-Bromo-2-(trifluoromethoxy)benzyl alcohol; [4-Bromo-2-(trifluoromethoxy)phenyl]methanol; 1-(4-Bromo-2-(trifluoromethoxy)phenyl)methanol; 2-(Trifluoromethoxy)-4-bromobenzyl alcohol; α-(4-Bromo-2-(trifluoromethoxy)phenyl)methanol; (4-Bromo-2-(trifluoromethoxy)phenyl)carbinol; 4-Bromo-α-(trifluoromethoxy)benzenemethanol
EINECS	Contact for details

Quality Control

Our (4-Bromo-2-(Trifluoromethoxy)Phenyl)Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (nitrogen or argon). Keep away from strong acids and oxidizing agents. Keep container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.