Description

2-Pyrimidinecarbonyl Chloride (9Ci) is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the efficient introduction of the 2-pyrimidinecarbonyl moiety, a key structural motif in bioactive molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides with specific modes of action.
• Ligand and Catalyst Development: Used to prepare functionalized pyrimidine-based ligands for metal complexes and organocatalysts.
• Material Science: Monomer or cross-linking agent for creating polymers with specialized electronic or thermal properties.
• Peptide Mimetics & Bioconjugation: Facilitates the coupling of pyrimidine derivatives to peptides, proteins, or other biomolecules for drug discovery and diagnostic applications.
• Custom Synthesis & Contract Research: Serves as a starting material for bespoke chemical synthesis services in R&D laboratories.

Basic Information

Product Name	2-Pyrimidinecarbonyl Chloride (9Ci)
CAS No.	220769-83-5
Molecular Formula	C5H3ClN2O
Molecular Weight	142.54 g/mol
Synonyms	Pyrimidine-2-carbonyl chloride; 2-Pyrimidinecarboxylic acid chloride; 2-Carbamoylpyrimidine chloride; 2-Pyrimidylcarbonyl chloride; Pyrimidine-2-carbonylchloride; 2-Pyrimidinecarbonylchloride; 2-Pyrimidine carboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Pyrimidinecarbonyl Chloride is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your synthetic processes. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. Certificates of Analysis (COA) are available for each lot upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.