Description

Ethanone, 2,2,2-Trifluoro-1-(2,4,5-Trimethylphenyl)- (9Ci) is a specialized trifluoromethyl ketone derivative, a high-value fluorinated building block prized for its unique electronic and steric properties. Its core value proposition lies in enabling the synthesis of complex molecules with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key fluorinated synthon for the development of new drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, facilitating the production of enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic electronic materials, contributing to properties like chemical resistance and tunable electronic characteristics.
• Chemical Biology Probes: Utilized as a building block for creating activity-based probes and fluorinated tags to study biological processes and protein interactions.

Basic Information

Product Name	Ethanone, 2,2,2-Trifluoro-1-(2,4,5-Trimethylphenyl)- (9Ci)
CAS No.	220675-88-7
Molecular Formula	C11H11F3O
Molecular Weight	216.20 g/mol
Synonyms	2,2,2-Trifluoro-1-(2,4,5-trimethylphenyl)ethanone; 1-(2,4,5-Trimethylphenyl)-2,2,2-trifluoroethanone; 2,4,5-Trimethyl-α,α,α-trifluoroacetophenone; α,α,α-Trifluoro-2,4,5-trimethylacetophenone; 2,2,2-Trifluoro-1-(2,4,5-trimethylphenyl)ethan-1-one; TFMPA derivative; Trifluoromethyl ketone intermediate
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2,2-Trifluoro-1-(2,4,5-Trimethylphenyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.