Description

Cyclohexanecarbonyl Chloride, 4-(Fluoromethyl)- (9Ci) is a high-value fluorinated organic intermediate with significant utility in advanced chemical synthesis. Its core value proposition lies in its dual functional groups—the acid chloride and the fluoromethyl moiety—which enable precise molecular construction for complex target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving performance characteristics.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, altering surface properties, solubility, and chemical resistance.
• Cross-Coupling Reactions: Acts as an electrophile in palladium-catalyzed and other metal-mediated coupling reactions to form carbon-carbon bonds.
• Peptide & Protein Research: Utilized as a derivatization or labeling agent in biochemical research due to its reactive acyl chloride group.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 4-(Fluoromethyl)- (9Ci)
CAS No.	220573-28-4
Molecular Formula	C8H12ClFO
Molecular Weight	178.63 g/mol
Synonyms	4-(Fluoromethyl)cyclohexanecarbonyl chloride; 4-(Fluoromethyl)cyclohexanoyl chloride; 4-Fluoromethyl-cyclohexanecarboxylic acid chloride; Cyclohexanecarbonyl chloride, 4-(fluoromethyl)-; 220573-28-4; 4-Fluoromethylcyclohexanecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our Cyclohexanecarbonyl Chloride, 4-(Fluoromethyl)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; ensure the container is kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.