Description

4-[3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Benzoyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive benzoyl chloride group and trifluoromethylpyrazole moiety. This compound matters for its critical role in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of the trifluoromethyl group is a key strategy for enhancing metabolic stability and bioavailability. Pharmaceutical and agrochemical R&D teams, as well as fine chemical manufacturers, need this building block to develop new generations of therapeutics and crop protection agents with improved efficacy.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in oncology, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for creating specialized polymers and liquid crystals with unique thermal and optical properties.
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Benzoyl Chloride
CAS No.	220461-85-8
Molecular Formula	C11H6ClF3N2O
Molecular Weight	274.62 g/mol
Synonyms	4-(3-(Trifluoromethyl)-1H-pyrazol-1-yl)benzoyl chloride; 1-[4-(Chlorocarbonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole; 4-(3-Trifluoromethylpyrazol-1-yl)benzoyl chloride; 220461-85-8; Benzoyl chloride, 4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]-; 4-(3-Trifluoromethyl-1H-pyrazol-1-yl)benzoyl chloride
EINECS	Contact for details

Quality Control

Our 4-[3-(Trifluoromethyl)-1H-Pyrazol-1-Yl]Benzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.