Description

4-Isoxazolecarbonylchloride,5-Amino-3-Methyl-(9Ci) is a high-purity, heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a versatile and reactive intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the isoxazole moiety for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers and organic electronic materials where the isoxazole ring contributes to specific electronic properties.
• Peptidomimetics and Bio-conjugation: The reactive acid chloride group enables efficient coupling reactions for creating peptide analogs and bioconjugates for biochemical studies.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector, enabling the production of bespoke compounds for client projects.

Basic Information

Product Name	4-Isoxazolecarbonylchloride,5-Amino-3-Methyl-(9Ci)
CAS No.	219938-18-8
Molecular Formula	C5H5ClN2O2
Molecular Weight	160.56 g/mol
Synonyms	5-Amino-3-methyl-4-isoxazolecarbonyl chloride; 3-Methyl-5-amino-4-isoxazolecarboxylic acid chloride; 4-Isoxazolecarbonyl chloride, 5-amino-3-methyl-; 5-Amino-3-methylisoxazole-4-carbonyl chloride; 3-Methyl-5-aminoisoxazole-4-carbonyl chloride; 4-Carbamoyl chloride-5-amino-3-methylisoxazole; 219938-18-8; 5-Amino-3-methyl-1,2-oxazole-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Isoxazolecarbonylchloride,5-Amino-3-Methyl-(9Ci) is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.