Description

Noscapine Hydrochloride Monohydrate is a high-purity pharmaceutical salt form of the naturally occurring alkaloid noscapine. This compound is valued for its antitussive (cough-suppressing) properties and is a key active pharmaceutical ingredient (API) in cough and cold formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in drug development and production. Consistent quality and reliable supply are critical for ensuring the efficacy and safety of the final medicinal products.

Application

• Pharmaceutical API: Primary use as the active ingredient in antitussive and cough syrup formulations.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Biomedical Research: Used in preclinical studies investigating its pharmacological properties, including potential anti-cancer and anti-inflammatory activities.
• Formulation Development: Employed in R&D for developing new solid dosage forms (e.g., tablets, capsules) and liquid preparations.
• Chemical Synthesis: Acts as a starting material or intermediate for the synthesis of novel noscapine derivatives with enhanced therapeutic profiles.

Basic Information

Product Name	Noscapine Hydrochloride Monohydrate
CAS No.	219533-73-0
Molecular Formula	C22H23NO7 • HCl • H2O
Molecular Weight	467.88 g/mol
Synonyms	Narcotine Hydrochloride Monohydrate; (-)-Noscapine Hydrochloride Monohydrate; 1-[(3R)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone Hydrochloride Monohydrate; Opian; Narcosine Hydrochloride Hydrate; Noscapine HCl Monohydrate; α-Narcotine Hydrochloride Monohydrate
EINECS	Contact for details

Quality Control

Our Noscapine Hydrochloride Monohydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and strength, suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	3.0% - 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.