Description

1H-Indole-3-Carbonyl Chloride,5-Fluoro- CAS NO 218771-36-9 is a high-value, fluorinated indole derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in its reactive carbonyl chloride group, which enables efficient coupling reactions to construct complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used to create novel fluorinated pesticides and herbicides, leveraging the fluorine atom's ability to enhance bioavailability and metabolic stability.
• Material Science: Employed in the development of specialty polymers and advanced organic electronic materials.
• Peptide Mimetics & Bioconjugation: Facilitates the introduction of the indole scaffold into peptides or proteins for biochemical studies and probe development.
• Academic & Contract Research: Serves as a versatile reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1H-Indole-3-Carbonyl Chloride,5-Fluoro- CAS NO 218771-36-9
CAS No.	218771-36-9
Molecular Formula	C9H5ClFNO
Molecular Weight	197.59 g/mol
Synonyms	5-Fluoro-1H-indole-3-carbonyl chloride; 5-Fluoroindole-3-carbonyl chloride; 5-Fluoro-1H-indole-3-carboxylic acid chloride; 5-Fluoroindole-3-carboxylic acid chloride; 3-Carboxy-5-fluoroindole chloride; 218771-36-9; 5-Fluoro-1H-indole-3-carbonylchloride
EINECS	Contact for details

Quality Control

Our production of 1H-Indole-3-Carbonyl Chloride,5-Fluoro- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.