Description

3'-Azido-3'-Deoxy-β-L-Adenosine is a chemically modified nucleoside analog, a crucial building block in medicinal chemistry and biochemical research. Its unique azido functional group at the 3' position makes it a valuable intermediate for click chemistry applications, enabling the synthesis of complex molecular probes and potential therapeutic agents. This compound is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on antiviral drug discovery, oligonucleotide synthesis, and the development of novel diagnostic tools.

Application

• Antiviral Research: Serves as a key intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) for investigating treatments against viral infections.
• Click Chemistry Reagent: The azido group enables efficient, site-specific conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling biomolecules.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for studying RNA function, stability, and as potential antisense therapeutics.
• Bioconjugation & Probe Development: Acts as a versatile handle for attaching fluorophores, affinity tags, or other functional groups to adenosine-based structures.
• Medicinal Chemistry: A critical scaffold for structure-activity relationship (SAR) studies to develop novel adenosine receptor ligands or enzyme inhibitors.
• Biochemical Tool: Employed in enzymatic studies to investigate the substrate specificity and mechanisms of nucleoside/nucleotide-processing enzymes.

Basic Information

Product Name	3'-Azido-3'-Deoxy-β-L-Adenosine
CAS No.	216976-76-0
Molecular Formula	C10H12N8O3
Molecular Weight	292.26 g/mol
Synonyms	3'-Azido-3'-deoxy-L-adenosine; 3'-N3-L-adenosine; 1-(3-Azido-3-deoxy-β-L-ribofuranosyl)adenine; L-3'-Azido-3'-deoxyadenosine; β-L-3'-Azido-2',3'-dideoxyadenosine; 3'-Azido-L-ddA; L-N3ddA; AZT-L-adenosine analog
EINECS	Contact for details

Quality Control

Every batch of 3'-Azido-3'-Deoxy-β-L-Adenosine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development applications, with specifications tailored to meet project requirements. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.