Description

1-Benzyloxycarbonylpiperidine-3-Carbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound matters because it serves as a critical building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients and other specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of piperidine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Peptidomimetic Synthesis: Used to introduce protected piperidine carboxylic acid moieties into peptide backbones to modify stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Custom Chemical Synthesis: Employed in contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.
• Agrochemical Research: Intermediate in the development of new crop protection agents and herbicides with novel modes of action.
• Academic Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	1-Benzyloxycarbonylpiperidine-3-Carbonyl Chloride
CAS No.	216502-94-2
Molecular Formula	C14H16ClNO3
Molecular Weight	281.73 g/mol
Synonyms	1-CBZ-Piperidine-3-Carbonyl Chloride; 3-(Chlorocarbonyl)-1-[(phenylmethoxy)carbonyl]piperidine; 1-[(Benzyloxy)carbonyl]-3-piperidinecarbonyl chloride; 1-N-CBZ-3-Piperidinecarbonyl Chloride; 1-N-Carbobenzyloxy-3-piperidinecarbonyl chloride; 3-Carbamoyl-1-CBZ-piperidine hydrochloride (precursor related); Piperidine-3-carboxylic acid, 1-[(phenylmethoxy)carbonyl]-, chloride
EINECS	Contact for details

Quality Control

Our 1-Benzyloxycarbonylpiperidine-3-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full batch data are provided to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in common organic solvents (DCM, THF, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.