Description

5-Fluoro-2-(trifluoromethyl)benzoyl chloride is a high-purity, multi-fluorinated benzoyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, acting as a reactive acyl chloride while introducing a strategically fluorinated aromatic core, which is essential for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, where the fluorine atoms enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides and fungicides, where the trifluoromethyl and fluorine substituents contribute to improved lipophilicity and biological activity.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated aromatic components in electronic display materials, enhancing thermal stability and optical properties.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and coatings, where it can be used to introduce fluorinated aromatic units to alter surface energy and chemical resistance.
• Peptide & Protein Modification: Acts as an acylating agent for modifying amino acid side chains or terminal amines in peptide research and bioconjugation.
• Chemical Research & Development: A versatile reagent for constructing complex, fluorinated molecular architectures in academic and industrial research settings.

Basic Information

Item	Detail
Product Name	5-Fluoro-2-(trifluoromethyl)benzoyl Chloride
CAS No.	216144-70-6
Molecular Formula	C8H3ClF4O
Molecular Weight	226.55 g/mol
Synonyms	5-Fluoro-2-(trifluoromethyl)benzoyl chloride; 2-Trifluoromethyl-5-fluorobenzoyl chloride; α,α,α-Trifluoro-5-fluoro-o-toluoyl chloride; 5-Fluoro-α,α,α-trifluoro-o-toluoyl chloride; Benzoyl chloride, 5-fluoro-2-(trifluoromethyl)-; 5-Fluoro-2-trifluoromethylbenzoyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-Fluoro-2-(trifluoromethyl)benzoyl chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with customer specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening and stored in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Ensure adequate ventilation in the storage area and keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.