Description

3-Fluoro-4-(Trifluoromethyl)Benzoyl Chloride is a high-value fluorinated aromatic acid chloride, serving as a critical building block in advanced organic synthesis. Its structure, featuring both fluorine and trifluoromethyl substituents, is engineered to impart unique electronic and steric properties to target molecules, enhancing their metabolic stability and lipophilicity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring fine-tuned bioactivity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, enhancing their dielectric anisotropy and stability.
• Polymer Modification: Employed to introduce fluorinated benzoyl groups into polymer chains, modifying surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: A versatile reagent for Friedel-Crafts acylation and nucleophilic acyl substitution reactions to introduce the 3-fluoro-4-(trifluoromethyl)benzoyl moiety.
• Advanced Material Research: Utilized in R&D for creating novel fluorinated compounds with specific optical, electronic, or surface-active properties.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethyl)Benzoyl Chloride
CAS No.	216144-68-2
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	4-(Trifluoromethyl)-3-fluorobenzoyl chloride; 3-Fluoro-α,α,α-trifluoro-p-toluoyl chloride; 3-Fluoro-4-trifluoromethylbenzoyl chloride; 2-Fluoro-α,α,α-trifluoro-4-methylbenzoyl chloride; 3-Fluoro-4-(trifluoromethyl)benzoic acid chloride; Benzoyl chloride, 3-fluoro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-(Trifluoromethyl)Benzoyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards and customer-specific requirements. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to guarantee identity, purity, and consistency. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.