Description

2, 2''-Diamino-2''-Deoxyadenosine (2''-Amino-2''-Deoxy-2, 6-Diaminopurineriboside) is a chemically modified nucleoside analog, a key building block in advanced oligonucleotide synthesis and medicinal chemistry research. This high-purity intermediate is critical for developing novel therapeutic agents, particularly antisense oligonucleotides and other nucleic acid-based modalities. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers focused on next-generation drug discovery.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Serves as a crucial modified monomer for constructing oligonucleotides with enhanced binding affinity and nuclease resistance.
• siRNA and miRNA Research: Used in the development of small interfering RNA (siRNA) and microRNA (miRNA) analogs for gene silencing applications.
• Medicinal Chemistry & Drug Discovery: Acts as a sophisticated scaffold for creating novel nucleoside-based prodrugs and antiviral/anticancer candidates.
• Bioconjugation and Probe Development: The additional amino groups provide handles for labeling with fluorescent dyes, affinity tags, or other functional moieties.
• Academic and Institutional Research: Employed in biochemical studies to investigate nucleic acid structure, function, and protein interactions.
• Contract Development and Manufacturing (CDMO): Supplied as a high-value raw material for the cGMP production of oligonucleotide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2, 2''-Diamino-2''-Deoxyadenosine
CAS No.	215943-79-6
Molecular Formula	C10H15N7O3
Molecular Weight	281.27 g/mol
Synonyms	2''-Amino-2''-deoxy-2,6-diaminopurineriboside; 2'-Amino-2'-deoxyadenosine (ambiguous, verify structure); 2,6-Diamino-9-(2-amino-2-deoxy-β-D-ribofuranosyl)purine; 2'-NH2-2'-dA; 2'-Amino-2'-deoxyadenosine analog; 9-[(2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-(methylamino)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one (related IUPAC); 2'-Amino-2'-deoxy-adenosine
EINECS	Contact for details

Quality Control

Our 2, 2''-Diamino-2''-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.