Description

3'-Azido-3'-Deoxy-5-Methyuridine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a crucial building block and intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery programs. The structural features of this molecule, including the azido group, make it a valuable precursor for click chemistry and other bio-conjugation strategies in medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral drug candidates.
• Antiviral Research: Used in the development of novel therapeutic agents targeting viruses such as HIV, Hepatitis B, and other retroviruses.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and the creation of modified nucleoside libraries.
• Bioconjugation & Probe Development: The azido functional group enables efficient conjugation via click chemistry (e.g., CuAAC) for creating labeled probes or drug-targeting constructs.
• Oncology Research: Investigated as a component in the development of nucleoside analogs with potential anticancer activity.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA/RNA metabolism and polymerase function.

Basic Information

Item	Details
Product Name	3'-Azido-3'-Deoxy-5-Methyuridine
CAS No.	215176-58-2
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	3'-Azido-3'-deoxy-5-methyluridine; 5-Methyl-3'-azido-3'-deoxyuridine; 3'-Azido-5-methyl-2',3'-dideoxyuridine; 3'-N3-5-Me-dU; AZT-MU Analog; 1-((2R,3S,5R)-3-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 3'-Azido-3'-Deoxy-5-Methyuridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.