Description

Vatalanib Succinate CAS NO 212142-18-2 is a high-purity, small molecule active pharmaceutical ingredient (API) primarily recognized for its potent and selective inhibition of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. This compound is critical for research and development in oncology, specifically targeting pathways involved in tumor angiogenesis. It is essential for pharmaceutical manufacturers, academic research institutions, and biotechnology companies engaged in the development of novel anti-cancer therapeutics and related preclinical studies.

Application

• Pharmaceutical API: Serves as the active ingredient in the formulation of investigational anti-cancer drugs.
• Oncology Research: Used as a key reference standard and tool compound in biochemical and cellular assays to study VEGF signaling pathways.
• Preclinical Development: Employed in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and toxicology profiles of angiogenesis inhibitors.
• Chemical Intermediate: Acts as a building block for the synthesis of more complex derivatives or prodrugs in medicinal chemistry programs.
• Quality Control: Utilized as an analytical standard in HPLC, LC-MS, and NMR methods for drug substance and product testing.

Basic Information

Product Name	Vatalanib Succinate
CAS No.	212142-18-2
Molecular Formula	C20H15ClF3N5O4 • C4H6O4
Molecular Weight	581.91 g/mol (for the succinate salt)
Synonyms	PTK787 Succinate; PTK787 ZK 222584 Succinate; ZK 222584 Succinate; Vatalanib (Succinate); N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine Succinate; 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1); CGP 79787D Succinate; PTK/ZK Succinate
EINECS	Contact for details

Quality Control

Our Vatalanib Succinate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by validated analytical methods including HPLC, NMR, and MS. We support compliance with cGMP standards for API production where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.