Description

Vatalanib Base CAS NO 212141-54-3 is a potent and selective small molecule inhibitor targeting vascular endothelial growth factor receptors (VEGFRs). This compound is a critical intermediate and active pharmaceutical ingredient (API) in the research and development of novel anti-angiogenic therapies. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions focused on oncology and ophthalmology.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of finished drug products targeting VEGFR pathways.
• Oncology Research: Used in preclinical and clinical research for developing treatments for solid tumors by inhibiting tumor angiogenesis.
• Ophthalmology Research: Investigated for applications in treating age-related macular degeneration (AMD) and other ocular neovascular diseases.
• Biochemical Assay Standard: Employed as a reference standard in high-throughput screening and enzymatic assays to study kinase inhibition.
• Mechanistic Studies: A vital tool for studying the role of VEGF signaling in various physiological and pathological processes.
• API Manufacturing: Used as the active ingredient in the pilot-scale and commercial-scale production of targeted cancer therapeutics.

Basic Information

Product Name	Vatalanib Base
CAS No.	212141-54-3
Molecular Formula	C₂₀H₁₅ClN₄
Molecular Weight	346.81 g/mol
Synonyms	PTK787; ZK 222584; Vatalanib; N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-; PTK787/ZK222584; ZK-222584; PTK-787
EINECS	Contact for details

Quality Control

Our Vatalanib Base is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via spectroscopic methods. We provide Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.