Description

Vatalanib Dihydrochloride is a potent and selective small-molecule inhibitor targeting vascular endothelial growth factor receptors (VEGFRs), primarily used in pharmaceutical research and development. This compound matters for its critical role in studying angiogenesis pathways and developing novel therapeutic agents for oncology applications. It is essential for pharmaceutical companies, biotechnology research labs, and academic institutions focused on cancer research, drug discovery, and preclinical studies.

Application

• Pharmaceutical Research & Development: Primary application as a reference standard and active pharmaceutical ingredient (API) in the development of anti-angiogenic cancer therapies.
• Oncology Drug Discovery: Used as a key biochemical tool to study VEGFR signaling pathways, tumor angiogenesis, and metastasis in preclinical models.
• Biochemical Assays: Serves as a potent inhibitor in high-throughput screening (HTS) and enzyme inhibition assays to evaluate compound libraries.
• Academic Research: Utilized in university and institutional labs for fundamental research on vascular biology and tyrosine kinase inhibitor mechanisms.
• Reference Standard: Employed as an analytical standard in quality control (QC) and method development for HPLC, LC-MS, and other analytical techniques.
• Preclinical Formulation Studies: Investigated in the development of various drug delivery systems, including nanoparticles and liposomes, for enhanced therapeutic efficacy.

Basic Information

Item	Detail
Product Name	Vatalanib Dihydrochloride
CAS No.	212141-51-0
Molecular Formula	C₂₀H₁₅N₅O • 2HCl
Molecular Weight	438.29 g/mol
Synonyms	PTK787 Dihydrochloride; ZK 222584 Dihydrochloride; Vatalanib 2HCl; N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride; 1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, dihydrochloride; PTK787/ZK 222584; CGP-79787D; ZK222584
EINECS	Contact for details

Quality Control

Our Vatalanib Dihydrochloride is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.