Description

2'-o-[2-[(Dimethylamino)Oxy]Ethyl]-5-Methyl-Uridine is a chemically modified nucleoside analog, a key building block in advanced oligonucleotide synthesis. This compound is specifically engineered to enhance the stability and binding affinity of therapeutic nucleic acids, such as antisense oligonucleotides and siRNA. It is an essential raw material for pharmaceutical R&D and production targeting genetic diseases, oncology, and antiviral applications.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A critical phosphoramidite precursor for constructing oligonucleotides with improved nuclease resistance and target affinity.
• Small Interfering RNA (siRNA) Development: Used to introduce stabilizing modifications into the siRNA guide or passenger strand to enhance pharmacokinetic properties.
• Therapeutic Aptamer Production: Serves as a modified monomer to increase the metabolic stability of nucleic acid aptamers for diagnostic and therapeutic use.
• Research on RNA Structure & Function: A valuable tool in biochemical research to study RNA-protein interactions and RNA stability mechanisms.
• Next-Generation Antiviral Drug Development: Incorporated into oligonucleotide sequences designed to inhibit viral replication.
• Diagnostic Probe Manufacturing: Used in the synthesis of high-specificity, stable probes for molecular diagnostics and genomic analysis.

Basic Information

Item	Detail
Product Name	2'-o-[2-[(Dimethylamino)Oxy]Ethyl]-5-Methyl-Uridine
CAS No.	212061-28-4
Molecular Formula	C14H21N3O7
Molecular Weight	343.33 g/mol
Synonyms	5-Methyl-2'-O-[2-[(dimethylamino)oxy]ethyl]uridine; 2'-O-(2-(Dimethylaminooxy)ethyl)-5-methyluridine; 2'-O-DMAOE-5-methyluridine; 5-Me-2'-O-DMAOE-U; 2'-O-[2-(N,N-Dimethylaminooxy)ethyl]-5-methyluridine; 2'-O-(2-Dimethylaminooxyethyl)-5-methyluridine; 2'-O-(2-(Dimethylamino)oxyethyl)-5-methyluridine; Uridine, 2'-O-[2-[(dimethylamino)oxy]ethyl]-5-methyl-
EINECS	Contact for details

Quality Control

Every batch of 2'-o-[2-[(Dimethylamino)Oxy]Ethyl]-5-Methyl-Uridine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical and diagnostic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.